An essential resource for understanding the scientific underpinnings of this emerging discipline, Pharmacogenomics: Applications to Patient Care is designed to prepare pharmacists to integrate pharmacogenomic principles into practice.

This book contains three modules in which the basics of genetics and pharmacogenomics are described and applications to specific therapeutic areas are highlighted. Each module includes content outlines, learning objectives, key words and abstracts, self-assessment questions and explained answers, and references to reinforce learning.

Pharmacogenomics: Applications to Patient Care is available in print and online formats. Continuing pharmacy education credit is available.

Continuing Education Credit Expired March 1, 2007

Module 1: Fundamentals of Applied Human Genomics
Introduces genetics and molecular and cellular biology, and how these disciplines can be used to explain the possible genetic basis for variability in drug response. Also discussed is the application of bioinformatics studies to pharmacogenomics and ethical issues in genomics.

Module 2: Fundamentals of Pharmacogenomics
Introduces the pharmacogenetics of oxidative drug metabolism, along with potential applications to tailoring drug therapy. A discussion of drug transporter pharmacogenetics includes localization and function, genetic variability, and clinical consequences. Drug target pharmacogenomics and pharmacogenetics, including the role of genetic variability in drug targets on drug efficacy and toxicity, and application to individualize drug therapy are explored.

Module 3: Pharmacogenomic Applications in Patient Care
Describes current and future pharmacogenomic applications for several therapeutic areas, including oncology and hematology, cardiovascular disease, infectious diseases, respiratory diseases, psychiatry, and transplantation.

Module 1: Fundamentals of Applied Human Genomics

• Principles of Genetic Medicine: Ronald G. Davidson, M.D., FRCPC, professor emeritus, McMaster University, Ancaster, Ontario; Joseph D. McInerney, M.A., M.S., National Coalition for Health Professional Education in Genetics, Lutherville, Maryland.
• Applied Molecular and Cellular Biology: Taimour Y. Langaee, Ph.D., MSPH, University of Florida, Gainesville; Issam Zineh, Pharm.D., University of Florida, Gainesville.
• Analysis of the Human Genome and Proteome: H. Trent Spencer, Ph.D., Emory University, Atlanta.
• Bioinformatics: Austin L. Hughes, Ph.D., University of South Carolina, Columbia.
• Applications of Genomics in Human Health and Complex Disease: Daren L. Knoell, Pharm.D., FCCP, The Ohio State University, Columbus; Wolfgang Sadee, Ph.D., professor emeritus, The Ohio State University, Columbus.
• Ethical, Legal, and Social Issues in Genomics: William L. Allen, J.D., University of Florida, Gainesville.

Module 2: Fundamentals of Pharmacogenomics

• Pharmacogenetics: A Historical Perspective: Werner Kalow, M.D., FRS, professor emeritus, University of Toronto, Toronto, Ontario, Canada.
• Pharmacogenetics of Oxidative Drug Metabolism and Its Clinical Applications: Reginald Frye, Pharm.D., Ph.D., University of Florida, Gainesville.
• Drug Transporter Pharmacogenetics: Deanna L. Kroetz, Ph.D., University of California, San Francisco; Tan D. Nguyen, Ph.D.c., University of California, San Francisco.
• Drug Target Pharmacogenetics: Julie A. Johnson, Pharm.D., FCCP, BCPS, University of Florida, Gainesville.
• Pharmacogenomics in Drug Discovery and Drug Development: John M. Valgus, Pharm.D., BCOP, University of North Carolina Hospitals, Chapel Hill.
• Societal and Ethical Issues in Pharmacogenomics: Pilar N. Ossorio, Ph.D., J.D., University of Wisconsin, Madison.

Module 3: Pharmacogenomic Applications in Patient Care

• Oncology and Hematology: Jill M. Kolesar, Pharm.D., FCCP, BCPS, University of Wisconsin, Madison.
• Infectious Diseases: P. David Rogers, Pharm.D., Ph.D., University of Tennessee, Memphis.
• Cardiovascular Diseases: Larisa H. Cavallari, Pharm.D., BCPS, University of Illinois, Chicago.
• Central Nervous System/Psychiatry: Vicki L. Ellingrod,Pharm.D., BCPP, University of Iowa, Iowa City; Jeffrey R. Bishop, Pharm.D., University of Iowa, Iowa City.
• Respiratory Diseases: John J. Lima, Pharm.D., Nemours Children's Clinic, Jacksonville; Jianwei Wang, M.D., Nemours Children's Clinic, Jacksonville.
• Transplantation: Gilbert J. Burckart, Pharm.D., University of Southern California, Los Angeles; HongXia Zheng, M.D., University of Southern California, Los Angeles.