This fifth edition of Fundamentals of Clinical Trials is written by recognized leaders who have long and extensive experience in all areas of clinical trials. Most chapters have been revised considerably from the fourth edition. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. Additionally, there is extensive new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials.

Features of the new edition:

• New chapter covers current regulatory issues and data monitoring is now covered in two chapters
• An essential, up-to-date reference for researchers and students involved with clinical trials
• Includes numerous examples of published clinical trials from a variety of medical disciplines
• Technical details are kept to a minimum through the use of graphs and tables
• The authors are active researchers leading clinical trials in a broad range of subjects