Pharmacogenomics offers the opportunity for clinicians to dramatically improve the health outcomes of millions of patients receiving drug therapy. However, this opportunity is tempered by the challenge of learning the seemingly limitless amount of genetic information assembled during the past decade, with new knowledge developing rapidly. ACCP has developed this textbook to assist clinicians in meeting this challenge. The enhanced second edition, written by leaders in pharmacogenomics from different practice areas, disciplines, and research environments, combines the basics of pharmacogenomics with disease-specific applications to give students and practitioners a solid foundation for understanding the basic science of pharmacogenomics and the skills for integrating pharmacogenomics into daily clinical practice. The third edition of Pharmacogenomics is scheduled to release in January 2015.

SECTION ONE–PHARMACOGENOMICS BASICS

• Chapter 1: Applications of Genomics in Human Health and Complex Disease
• The Rich Life of a Poor Metabolizer – Tribute to Werner Kalow, M.D.
• Chapter 2: Pharmacogenetics: A Historical Perspective
• Chapter 3: Pharmacogenetics of Oxidative Drug Metabolism and Its Clinical Applications
• Chapter 4: Phase II Drug-Metabolizing Enzymes
• Chapter 5: Drug Transporter Pharmacogenetics
• Chapter 6: Drug Target Pharmacogenetics
• Chapter 7: Pharmacogenomics in Drug Discovery and Drug Development

SECTION TWO–PHARMACOGENOMICS APPLICATIONS IN TREATING DISEASE

• Chapter 8: Pharmacogenomics of Solid Tumors
• Chapter 9: Pharmacogenomics of Hematologic Malignancies
• Chapter 10: Warfarin Pharmacogenetics
• Chapter 11: Infectious Diseases
• Chapter 12: Cardiovascular Diseases
• Chapter 13: Psychiatry
• Chapter 14: Respiratory Diseases
• Chapter 15: Transplantation

SECTION THREE–ETHICAL, LEGAL, SOCIAL, AND REGULATORY ISSUES

• Chapter 16: Ethical, Legal, and Social Challenges to Applied Pharmacogenetics
• Chapter 17: Cost-effectiveness, Economic Incentives, and Reimbursement Issues
• Chapter 18: Ethical and Privacy Issues in Pharmacogenomic Research

SECTION FOUR–FUNDAMENTALS OF APPLIED HUMAN GENOMICS

• Chapter 19: Principles of Genetic Medicine
• Chapter 20: Applied Molecular and Cellular Biology
• Chapter 21: Analysis of the Human Genome and Proteome
• Chapter 22: Bioinformatics

Howard L. McLeod, Pharm.D., FCCP - Chair
University of North Carolina
Eshelman School of Pharmacy
Chapel Hill, North Carolina

C. Lindsay DeVane, Pharm.D., FCCP, BCPP
Medical University of South Carolina
Department of Psychiatry
Charleston, South Carolina

Susanne B. Haga, Ph.D.
Duke University
Institute for Genome Sciences and Policy
Durham, North Carolina

Julie A. Johnson, Pharm.D., FCCP, BCPS
University of Florida
Department of Pharmacotherapy and Translational Research
Center for Pharmacogenomics
Gainesville, Florida

Daren L. Knoell, Pharm.D., FCCP
The Ohio State University
College of Pharmacy
Columbus, Ohio

Jill M. Kolesar, Pharm.D., FCCP, BCPS
University of Wisconsin
School of Pharmacy
Madison, Wisconsin

Joseph D. McInerney, M.A., M.S.
National Coalition for Health Professional Education in Genetics
Lutherville, Maryland

P. David Rogers, Pharm.D., Ph.D., FCCP
University of Tennessee Health Science Center
Department of Clinical Pharmacy
Memphis, Tennessee

Joseph R. Walker, Pharm.D.
Daiichi Sankyo Pharma Development
Edison, New Jersey

Also available: Pharmacogenomics: Applications to Patient Care Self-Assessment Tool