The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy.

New with this edition:

• new title reflects increased emphasis on drug pharmacodynamics because of the evolution and growing wealth of knowledge from new research in the area
• new series of case studies helps readers apply concepts they examine in the text to actual patient problems
• five new chapters: "Critical Evaluations of Methods for Therapeutic Drug Monitoring," "Tacrolimus," "Mycophenolic Acid," "Sirolimus," and "Antipsychotics"
• new appendix provides information on outcome studies with therapeutic drug monitoring
• more drawings and reference tables provide rapid access to key information for more effective and efficient learning

Michael E. Burton, Pharm.D.; Leslie M. Shaw, Ph.D.; Jerome J. Schentag, Pharm.D.; William E. Evans, Pharm.D.

ISBN 0-7817-4431-8; 2005; 867 pages; hardbound