Original Research
Saturday, November 11, 2023
11:30 AM–01:00 PM
Abstract
Introduction:
Intravenous iron therapy is recommended in patients with heart failure (HF) with reduced ejection fraction. However, little evidence evaluated predictors to achieve iron deficiency treatment goals with intravenous iron therapy.
Research Question or Hypothesis:
What are significant predictors for the achievement of iron deficiency treatment goals using intravenous iron therapy?
Study Design:
Single center retrospective cohort study
Methods:
The study inclusion criteria were patients older than 18 years of age diagnosed with HF or pulmonary hypertension who met the criteria for iron deficiency. Primary outcome was an iron deficiency treatment goal defined as hemoglobin > 15 mg/dL or iron studies (either ferritin > 300 ng/mL or ferritin 100-299 ng/mL and iron saturation > 20 %). Age, weight, body mass index, gender, ejection fraction, baseline ferritin, baseline iron saturation, absolute iron deficiency (versus. functional iron deficiency), baseline hemoglobin, SGLT-2 inhibitor use, total intravenous iron amount during induction course, and intravenous iron indication were evaluated as predictors. Univariate logistic regression analyses were conducted to investigate the association between the predictors and the primary outcome. All statistical analyses were performed using R 4.3.0 (R Core Team, Vienna Austria).
Results:
A total of 123 patients were included. Baseline iron saturation (odds ratio (OR) 2.15; 95% confidence interval (CI): 1.04, 4.47; p = 0.040) and HF with reduced ejection as an indication for intravenous iron therapy (OR 3.03; 95% CI: 1.29, 7.13; p = 0.011) were significant predictors for the achievement of iron deficiency treatment goals. There were also significant non-linear relationships between baseline hemoglobin (OR 1.49; 95% CI 0.82, 2.69; p=0.039) and body mass index (OR 0.53; 95% CI 0.26, 1.10; p=0.014) and achievement of iron deficiency treatment goals.
Conclusion:
Higher baseline iron saturation, higher baseline hemoglobin, lower body mass index, HF with reduced ejection fraction as an indication for intravenous iron therapy were the significant predictors of achieving iron deficiency treatment goals.
Presenting Author
Kazuhiko Kido Pharm.D.South Dakota State University College of Pharmacy and Allied Health Professions
Authors
Marco Caccamo D.O.
West Virginia University School of Medicine
Wei Fang PhD
George Sokos D.O.
West Virginia University School of Medicine