Scientific Poster Session IV - Original Research

Original Research
  Tuesday, November 14, 2023
  08:30 AM–10:00 AM

Abstract

Introduction: The Minnesota Assessment of Pharmacogenomic Literacy (MAPL) was recently developed and validated in English, but its generalizability in evaluating PGx literacy in other cultural settings and languages, such as Chinese, remains to be determined.

Research Question or Hypothesis: To validate the Chinese version of MAPL (MAPL-C), assess PGx literacy among native Chinese speakers, and compare response patterns to the English MAPL.

Study Design: Cross-sectional

Methods: The MAPL was converted to the MAPL-C following cross-cultural translation guidelines. A national online survey in China was conducted to validate the MAPL-C and assess PGx literacy among a random sample of Chinese speakers. Validation included factor analysis, characterization of response patterns, and associations with sociodemographic and health-related characteristics. High-quality responses 959 from adult Chinese respondents were included. Psychometric characteristics and response patterns were then compared with previously obtained MAPL data from the U.S. study sample (n=646).

Results: Participants were predominantly Han Chinese (96.3%), males (54.5%), aged 18-29 (70.9%), with at least some college education (95.0%). Chinese participants’ performance on the 13-item MAPL-C revealed a three-factor model (i.e., concepts, limitations, and privacy), as compared to a single factor structure in U.S. participants. Results from the Chinese sample indicated less understanding of the limitations of PGx testing relative to other domains. Higher health literacy correlated with higher MAPL-C scores in the Chinese, but not the U.S. respondents. Higher PGx literacy was associated with younger age, higher education, and prior experience with genetic testing in both study samples.

Conclusion: Through the development and validation of the MAPL-C, we identified similarities in items that quantified PGx knowledge and associations with sociodemographic and heath variables in Chinese and U.S. participants. Differences in the recognition of PGx limitations and the factor structure of response patterns across study samples underscores the importance of population specific validation and interpretation of results.

Presenting Author

Jeffrey R. Bishop PharmD, MS, BCPP, FCCP
University of Minnesota

Authors

Josiah Allen PharmD
St. Elizabeth Healthcare

Amy Pittenger Pharm.D., MS, Ph.D.
University of Minnesota College of Pharmacy

Fan Wang MS, PhD
University of Minnesota College of Pharmacy

Lusi Zhang PharmD, MHI
University of Minnesota

Shuqin Zhou MD, MS
Tongji University