Advances in International Clinical Pharmacy Practice, Education, or Training
Sunday, November 12, 2023
12:45 PM–02:15 PM
Abstract
Service or Program:
Standardized protocols set forth by Global Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS) were used to record antimicrobial consumption data and several quality indicators from 4 local hospitals in Guatemala. The surveys were conducted by team composed of pharmacists, infection control nurses, and physicians and then validated by the assigned site coordinator. The antibiotic data was then categorized according to the 2021 World Health Organization (WHO) AWaRe classifications to help identify antibiotic use trends in the various wards of the hospital.
Justification/Documentation:
After reviewing 1177 patient charts, there were 642 (54.5%) patients prescribed at least one antimicrobial. From the 1082 total prescriptions, 957 (88.4%) were systemic antibiotic prescriptions with carbapenems, penicillins with beta-lactamase inhibitors and 3rd generation cephalosporins (17.9%, 14.1% and 11.3% respectively). Many of the antibiotics prescribed were in the WHO Watch category creating concern for rising antimicrobial resistance (AMR) and development of multidrug resistant organisms (MDRO). As one of the first cross-sectional Global-PPS studies conducted in Guatemala, a goal was to the provide direction for future category use targets such as decreasing Watch category prescriptions.
Adaptability:
This multicenter review of antimicrobial prevalence in Guatemala ranged from tertiary to specialized referral centers demonstrating the ease of the Global-PPS being a web-based application to collect antimicrobial data. The ability to compare the collected data at an international level allows this process to repeated at other institutions globally who are looking to make improvements to their antimicrobial stewardship programs (ASPs).
Significance:
With the increasing rise MDROs, particularly carbapenem resistant A. baumannii and third generation cephalosporin-resistant E. coli in Guatemala, it is imperative to conduct studies like this to observe the baseline antimicrobial use after implementation of ASPs, which can guide the design of future interventions and move towards institution standardized guidelines to better support hospital staff.
Presenting Author
Sylvia Choi B.S.UCSF
Authors
Randall Lou-Meda MD, MSc, MA
Herberth Maldonado MD
Mario Melgar MD
Herman Goossens MD
Diala Mudawar B.S.
UCSF
Ingrid Muj -
Estephany Muñoz Hernandez -
Ines Pauwels MPharm
Alejandra Escobar -
Ann Versporten MPH
Brooke Ramay PharmD
Jennifer Rojas -