Students Research in Progress
Monday, November 13, 2023
01:00 PM–02:30 PM
Abstract
Introduction:
Dialysis centers under Medicare Prospective Payment System receive fixed reimbursement for services and medications, including calcimimetics like etelcalcetide and cinacalcet. Recent studies have shown that cinacalcet, administered thrice weekly (TIW) at dialysis clinics, is a cost-effective and adherence-promoting alternative to etelcalcetide. UI Health dialysis has implemented this dosing regimen to improve patient adherence and cost-efficiency
Research Question or Hypothesis: Are clinical outcomes of cinacalcet comparable to etelcalcetide in terms of cost-effectiveness and adherence promotion among the hemodialysis population at UI Health?
Study Design: This retrospective study includes patients aged 18 years or older enrolled at UI Health outpatient hemodialysis center from January 2019 to May 2023. The study compares patients receiving either etelcalcetide or cinacalcet during the specified period.
Methods: The retrospective study used electronic health records (EPIC) and Microsoft Excel to document and identify laboratory values relevant to managing secondary hyperparathyroidism (SHPT). It also noted transition dates from etelcalcetide to TIW cinacalcet dosing.
Results: Patients had a mean PTH of 557.9 ± 71.7 pg/mL before receiving TIW cinacalcet. Following the regimen, the mean PTH observed was 565.9 ± 103.4 pg/mL. Patients newly initiated on cinacalcet had a mean PTH of 826.3 ± 250.2 pg/mL and decreased to a mean PTH of 769.2 ± 77.7 pg/mL. The mean dose of cinacalcet post-transition was 48.9 ± 25.2 mg.
Conclusion: Thrice-weekly administration of cinacalcet effectively manages SHPT in ESRD patients and optimizes cost-efficiency and patient adherence. Successful control of PTH levels was observed in patients switching from etelcalcetide to thrice-weekly cinacalcet and in those initiating treatment with the intermittent cinacalcet regimen.
Presenting Author
Beatrice Drambarean PharmD, B.SUniversity of Illinois at Chicago
Authors
Ahmed Gharib N/A
University of Illinois at Chicago College of Pharmacy
Karol Suarez B.S
University of Illinois at Chicago College of Pharmacy