Students Research in Progress
Saturday, November 11, 2023
11:30 AM–01:00 PM
Abstract
Introduction: Acute respiratory distress syndrome (ARDS) is a common and lethal disease with no specific drug treatment. Disease heterogeneity and late diagnosis are likely culprits for the poor outcomes. Much work has been done to identify biomarker-defined phenotypes of ARDS; however, little has been done to predict patients that will develop ARDS soon after admission. The Lung Injury Prediction Score (LIPS) is the only validated score to predict the development of ARDS in hospitalized patients, but it has low predictive value. Enriching the LIPS with specific biomarkers may improve its predictive ability. Matrix-metalloproteinase 3 (MMP3) may serve as an optimal biomarker for this purpose due to its involvement in the pathophysiology of ARDS development.
Research Question or Hypothesis: Does MMP3 alone or in addition to the LIPS increase predictive value for development of ARDS when compared to the LIPS?
Study Design: Prospective observational cohort study.
Methods: Adult patients admitted to the ICU requiring supplemental oxygen over baseline requirement with a LIPS >/= 6 will be included. Patients with hospital admissions >24 hours, baseline ESRD, or <100 mcL plasma available will be excluded. Whole blood will be collected in collaboration with the institutional core laboratory, centrifuged, and MMP3 measured. Plasma MMP3 activity will be measured with an MMP3 activity fluorescence resonance energy transfer assay. Biomarker and clinical data will be collected for 7 days after sample collection to determine development of ARDS based on Berlin Criteria and other relevant outcomes.
Results: Research in progress.
Conclusion: Research in progress.
Presenting Author
Andrew Bennett PharmD CandidateUniversity of Georgia College of Pharmacy
Authors
Sultan Almuntashiri PharmD
University of Georgia College of Pharmacy
Aaron Chase Pharm.D., BCCCP
Augusta University Medical Center
Duo Zhang PhD
University of Georgia College of Pharmacy
Andrea Sikora Newsome PharmD, MSCR, BCCCP, FCCM
Augusta University Medical Center/UGA College of Pharmacy