Students Research in Progress
Tuesday, November 14, 2023
08:30 AM–10:00 AM
Abstract
Introduction: How to effectively alleviate perioperative pain in hip joint diseases is currently a hot topic. We selected parecoxib with higher safety as the study drug to evaluate the clinical comprehensive value of parecoxib in the perioperative pain management of the elderly hip, so as to promote clinical rational medication and provide evidence support.
Research Question or Hypothesis: Is it more safe, effective, economical, innovative, suitable, and accessible to use parecoxib for pain relief in elderly hip joint patients during the perioperative period?
Study Design: Qualitative and quantitative evaluations of safety and effectiveness are conducted using literature research and prospective observational research methods; Economy, innovation, suitability, and accessibility were evaluated using the Delphi method to construct evaluation indicators and collect drug related information for descriptive evaluation.
Methods: 1. Safety and effectiveness research: Using methods such as system evaluation, meta-analysis, and real-world research, data processing is carried out using software such as Review management, Spss. 2. Research on Economy, Innovation, Suitability, and Accessibility: Apply cost-effectiveness analysis and evidence-based medicine methods in pharmaceutical economics, and use software such as Treeage Pro for data processing.
Results: 1. Safety and Effectiveness-Literature Research Section: After screening the literature, 36 randomized controlled studies were ultimately included. The meta-analysis results showed that the perioperative use of parecoxib in elderly hip joint patients relieved acute pain for at least 24 hours, reduced postoperative demand for opioids, and had no impact on the incidence of adverse reactions. 2. Economy, innovation, suitability, and accessibility research: After two rounds of expert consultation, 7 secondary indicators and 15 tertiary indicators have been established, and relevant information on the established indicators is currently being collected.
Conclusion: 1. Compared with placebo, the perioperative use of parecoxib in elderly hip joint patients has better safety and effectiveness. 2. Compared with fentanyl, dexamethasone, flurbiprofen axetil, and ketoprofen tromethamine, parecoxib has higher safety.
Presenting Author
Zhuoqi Ge Professional Master of PharmacyGuizhou Medical University
Authors
Mingnian Li Professional Master of Pharmacy
Guizhou Medical University
Qi Chen Doctor of Philosophy
Guizhou Provincial People's Hospital
Ruojun Yuan Professional Master of Pharmacy
Guizhou University of Traditional Chinese Medicine
Benqi Zhang Professional Master of Pharmacy
Guizhou Medical University
Yufeng Sun Professional Master of Pharmacy
Guizhou University of Traditional Chinese Medicine