Scientific Poster Session IV: Residents and Fellows Research-in-Progress

Residents and Fellows Research in Progress
  Tuesday, November 14, 2023
  08:30 AM–10:00 AM

Abstract

Introduction:

Epinephrine is recommended for adults with cardiac arrest at a standard, non-weight-based dose of 1 mg derived from canine studies and intracardiac epinephrine use during surgery. Standard dose epinephrine demonstrated increased return of spontaneous circulation (ROSC) and survival to hospital discharge after out-of-hospital cardiac arrest. High-dose and low-dose regimens have been studied but have not been associated with improved survival and are not recommended. No epinephrine dosing strategy has been associated with favorable neurologic outcomes. Weight-based dosing is only recommended in pediatrics, and few studies have evaluated weight-based dosing in adults. The purpose of this study is to assess the efficacy of standard doses of epinephrine in adult patients with variable body weights to identify a need for alternative dosing regimens in underweight or overweight patients.

Research Question or Hypothesis:

Is the achievement of ROSC after administration of standard doses of epinephrine for in-hospital cardiac arrest (IHCA) associated with patient body weight?

Study Design:

This is an institutional review board-approved retrospective chart review of adult patients at CHRISTUS Mother Frances Hospital– Tyler who received epinephrine for IHCA between June 15, 2022, and June 15, 2023.

Methods:

Patients aged 18 years or older with documented body weights who received at least one standard dose of intravenous (IV) or intraosseous (IO) epinephrine during IHCA will be included. Patients will be divided into three body weight groups: less than 50 kg, 50 to 120 kg, and greater than 120 kg. The primary outcome is the achievement of ROSC. Secondary outcomes include survival to hospital discharge with favorable neurologic outcome, incidence of post-ROSC ischemic events, intensive care unit and hospital length of stay, 30-day mortality, and recurrence of cardiac arrest after ROSC. Results will be analyzed using descriptive statistics.

Results:

Research in progress

Conclusion:

Research in progress

Presenting Author

Mary Margaret Bliss PharmD
CHRISTUS Mother Frances Hospital

Authors

Kelsey Lock PharmD
CHRISTUS Trinity Mother Frances Health System

Corey Cicci PharmD, BCPS, BCEMP
CHRISTUS Trinity Mother Frances Health System

Craig Cocchio PharmD, BCPS, DABAT
Christus Trinity Mother Frances