Students Research in Progress
Tuesday, November 14, 2023
08:30 AM–10:00 AM
Abstract
Introduction:
Sepsis and septic shock management typically involves administration of large volumes of intravenous fluids. Following fluid resuscitation, diuretics are often ordered in the intensive care unit (ICU) for de-resuscitation to improve fluid balance. Previous literature has shown a large portion of patients initiated on diuretics for de-resuscitation continue diuretics on ICU and hospital discharge. The goals of this study are to describe diuretic use in septic and septic shock patients and expand on the limited existing research on factors that may influence the risk of diuretic continuation.
Research Question or Hypothesis:
How often are diuretics which were initially prescribed in the ICU for fluid de-resuscitation continued upon discharge, and what factors predict continuation?
Study Design:
Single-center, retrospective, cohort study
Methods:
All patients admitted to the medicine ICU with sepsis from February 2023 to May 2023 who received intravenous fluid resuscitation will be identified. The following will be collected: patient demographics, medication regimen complexity ICU score, Charlson comorbidity index, diuretic prescriptions during ICU stay, diuretic prescriptions within 48 hours of transition from ICU, discharge diuretic prescriptions. Additional information such as use of albumin or hypertonic saline, additional fluid boluses following initial fluid resuscitation, therapy to correct electrolytes, and development of acute kidney injury in the ICU will be assessed. The study population will be characterized using descriptive statistics (mean and SD, number and percentage). To assess factors associated with diuretic continuation after transitions, categorical variables will be analyzed using Pearson ?2 tests, while continuous variables will be analyzed using Students t tests.
Results:
N/A (research in progress)
Conclusion:
N/A (research in progress)
Presenting Author
Amber Woolley PharmD CandidateUniversity of Oklahoma College of Pharmacy
Authors
Jordan Fuller PharmD, MBA
University of Oklahoma College of Pharmacy
Brooke Robbins PharmD Candidate
University of Oklahoma College of Pharmacy