Scientific Poster Session III: Students Research-in-Progress

Abstract

Research Question or Hypothesis:

Study Design:

Methods:

This systematic review will provide a comprehensive assessment of published literature using the PubMed database from inception through August 2023. Investigators identified a list of antimicrobials commonly used in infections experienced frequently in women who are lactating (e.g., post C-section surgical site infection, gynecologic infections) and conducted a search of the PubMed database using combination search terms that included the drug name with lactation or breastfeeding. Additionally, searches of “antibiotics/antivirals/antifungals and lactation” were performed. Original research articles in English, including case reports/series, were screened for inclusion. Reference lists of included articles and review articles were screened. The National Institute of Health’s National Center for Biotechnology Information (NIH NCBI) PubChem platform was used to determine drug characteristics to include in the analysis, especially when very little published evidence was available. The FDA Adverse Event Reporting System (FAERS) database was searched using the generic name of included antimicrobials to identify any exposures documented via breast milk. Safety was determined by minimal drug exposure in the breast milk relative to each drug, no severe adverse reactions in the newborn, and favorable characteristics such as high molecular weight and protein binding. Investigators used the available evidence to provide recommendations on safe and effective use, especially in an era of emerging resistance.

Results:

Conclusion: