Original Research
Tuesday, October 15, 2024
08:30 AM–10:00 AM
Abstract
Introduction: Polypharmacy may lead to adverse health outcomes in older adults, but the relationship between polypharmacy and accelerated aging is not well understood.
Research Question or Hypothesis: This study aimed to investigate the association between polypharmacy and a-klotho, a blood anti-aging protein, using large population-based data.
Study Design: This cross-sectional study utilized data collected from the National Health Examination Survey (NHANES, 2007-2016), a nationally representative survey of the noninstitutionalized civilian residents in the United States, by using a stratified, multistage, and probability sampling design.
Methods: 3569 participants aged 65-79 years with serum a-klotho test data and prescription information were included. Participants taking 5 or more medications simultaneously were classified as having polypharmacy. Weighted multiple linear regression analyses were performed to examine the association between polypharmacy and a-klotho. Mediation analysis was performed to examine the effect of inflammatory markers, including the systemic inflammation response index (SIRI), systemic immune-inflammation index (SII), and neutrophil-to-lymphocyte ratio (NLR), on the relationship between polypharmacy and a-klotho levels.
Results: The polypharmacy group consisted of 1,591 participants (weighted percentages 42.7%). The weighted median level of a-klotho in the polypharmacy group was 733.16[594.47, 911.63] pg/mL, which was significantly lower than that in the non-polypharmacy group. After adjustment for multiple covariables, polypharmacy remained significantly negatively associated with a-klotho (weighted ß-coefficient -0.0506, 95% CI -0.0855 to -0.0157), and this significant association was observed in men and women, respectively. Mediation analyses revealed that the association between polypharmacy and a-klotho was mediated by inflammatory markers, with the proportion of mediation being 11.82% (SIRI, p<0.01), 9.14% (SII, p<0.001),6.11% (NLR, p<0.01), respectively.
Conclusion: These findings suggest that polypharmacy is closely linked to circulating a-klotho levels, which may be partly mediated by inflammation.
Presenting Author
Kai Wei PhDGuizhou Provincial People's Hospital
Authors
Chun Chen MS
Guizhou Provincial People's Hospital
Shuimei Sun MS
Guizhou Provincial People's Hospital
Libin Wang MS
Guizhou Provincial People's Hospital
Yanping Yang MS
Guizhou Provincial People's Hospital