Original Research
Monday, October 14, 2024
01:00 PM–02:30 PM
Abstract
Introduction: This study examines off-label prescription practices in the U.S. and evaluates pharmacy students' understanding of such uses, which are often under-discussed in therapeutic courses. The study identifies gaps in literature and education related to off-label drug applications, highlighting the relevance to clinical pharmacy.
Research Question or Hypothesis: The research investigates two key questions: "What is the level or availability of literature on off-label drug uses?" and "What is the understanding among pharmacy students regarding these uses?"
Study Design: A survey was administered along with a literature search to forty pharmacy students to assess their knowledge and opinions on the off-label uses of albuterol, gabapentin, and tamsulosin.
Methods: Using a standardized questionnaire (a total of 45 knowledge and 45 opinion questions), we evaluated students' knowledge on drug side effects, interactions, indications, and formulations, with a primary focus on off-label uses. Responses were analyzed using descriptive statistics, chi-square tests, and multi-regression analysis in SPSS, targeting a 0.05 significance level.
Results: Students achieved an average correctness rate of 52.21% across 30 knowledge questions. Detailed results indicated strong knowledge in identifying side effects, such as 86.5% recognizing tachycardia from albuterol. However, significant knowledge gaps were evident in off-label uses; only 59.5% understood that albuterol is not approved for bacterial infections and correctly identified its tablet form. Most of them also do not believe in promoting the off-label use of medications. These gaps underscore the need for enhanced educational focus on off-label drug uses to improve safe prescribing practices.
Conclusion: Although pharmacy students are generally knowledgeable about medication safety, there are substantial gaps in their understanding of off-label uses. There is a lack of literature in guiding practitioners in the off-label uses of medications. This study underscores the importance of integrating comprehensive education on off-label prescribing into pharmacy training programs.
Presenting Author
Bisrat Hailemeskel MS., Pharm.D, ABAAHP, RPh, Professor & Vice-ChairHoward University
Authors