Scientific Poster Session I - Original Research

Original Research
  Saturday, October 12, 2024
  11:30 AM–01:00 PM

Abstract

Introduction: Attainment of LDL-C levels < 70 mg/dl with lipid lowering therapy (LLT) is associated with decreased rates of ASCVD events. However, studies show up to 58% of patients have LDL-C > 70 mg/dL one year after coronary revascularization and less than half had their LLT intensified.

Research Question or Hypothesis: How are lipids being evaluated and managed in patients with various forms of ASCVD following revascularization?

Study Design: We report a retrospective cohort study evaluating LLT intensification in patients with ASCVD after coronary, cerebral, or peripheral revascularization between July 2021 – July 2022.

Methods: Patients were identified from procedure lists. Exclusion criteria included baseline LDL-C < 70 mg/dl, triglycerides > 500 mg/dl, dialysis dependence, and no follow-up care within 6 months of revascularization. Baseline lipids and LLT were compared to follow-up metrics within 15 months post-revascularization. The primary outcome was achievement of LDL-C < 70mg/dL at 15 months. Secondary outcomes included percentage of patients with follow-up lipid panel, time to follow-up lipid panel, LLT intensification after revascularization, and achievement of LDL-C < 70mg/dL at 15 months in patients with early follow-up lipid panel (within 3 months) after revascularization.

Results: One-hundred fifty-nine patients were included. Within 15 months, 69 (43%) patients had a follow-up lipid panel for evaluation, 35 (51%) of whom achieved an LDL-C < 70mg/dL at an average of 162±115 days following revascularization. Only 28 (18%) patients had LLT intensified. LDL-C goal was achieved more frequently in patients with coronary (56%) and peripheral (46%) revascularization compared to cerebral revascularization (17%); only 3% of patients with cerebral revascularization had LLT intensified. Early lipid panel measurement made no significant difference in patients meeting LDL-C goal.

Conclusion: High-risk ASCVD patients do not receive appropriate lipid follow-up and have low rates of achieving LDL-C goals within 15 months post ASCVD revascularization.

Presenting Author

Hannah Ayers PharmD
University of Illinois Chicago

Authors

Ali Alaraj MD, MHA, FAHA, FACS
University of Illinois Chicago

Robert J. DiDomenico PharmD, FCCP, FHFSA, FACC
University of Illinois at Chicago College of Pharmacy

Melissa Duckett DNP, APRN, AG-ACNP-BC
University of Illinois Chicago

Stephanie Dwyer Kaluzna PharmD, BCCP
University of Illinois Chicago

Vicki L. Groo PharmD, BCCP, CHC
University of Illinois at Chicago

Erika Hellenbart PharmD, BCPS
University of Illinois at Chicago College of Pharmacy

Peter Theiss MD
University of Illinois Chicago

David Tofovic MD
University of Illinois Chicago