Scientific Poster Session II - Original Research

Original Research
  Sunday, October 13, 2024
  12:45 PM–02:15 PM

Abstract

Introduction: There is a hypothesized correlation between the use of serotonergic reuptake inhibitors and an increased risk of bleeding complications in the perioperative space. However, there is significant heterogeneity in these studies, with variations observed between methodology and surgical types. This study aims to quantify the risk of perioperative SSRI and SNRI usage and associated bleeding in partial hepatectomies.

Research Question or Hypothesis: Is there a statistically significant difference in intraoperative blood loss for patients on a home SSRI/SNRI following partial hepatectomies?

Study Design: A retrospective chart review of adult patients who underwent a partial hepatectomy. Pharmacy medication records were used to determine SSRI/SNRI usage.

Methods: This is a retrospective cohort study of patients across Indiana University Health who underwent partial hepatectomy procedures from 2018 to 2023. Exclusion criteria included procedures aborted for reasons other than bleeding, recipients or donors of a liver, compliance status of “not taking” on home medication list, and/or multiple operative surgeries. Patients were grouped based on SSRI/SNRI usage. The primary outcome is intraoperative blood loss differences. Secondary outcomes include length of stay, hospital mortality, and changes in hemoglobin.

Results: Of the 130 patients included, 65 patients reported usage of an SSRI/SNRI at home while 65 patients did not. No statistically significant distinction was observed in intraoperative blood loss (mL) between the two groups (300 vs 300, p = 0.942). No variations in length of stay (days) (6.27 vs 6.28, p= 0.476), inpatient mortality (2 vs 0, p=0.496), and change in hemoglobin (g/dL) during admission (2.89 vs 2.68, p= 0.46) were noted.

Conclusion: Home utilization of SSRIs/SNRIs showed no difference in intraoperative bleeding, endorsing the continuation of SSRIs and SNRIs for patients undergoing partial hepatectomies. Further prospective research is warranted to validate these findings.

Presenting Author

Medina Halimanovic PharmD
Indiana University Health

Authors

Eliza Duncan PharmD
Indiana University Health

Mackenzie Page PharmD
Indiana University Health