Scientific Poster Session I - Original Research

Original Research
  Saturday, October 12, 2024
  11:30 AM–01:00 PM

Abstract

Introduction: The kidney donor profile index (KDPI) is used to qualify deceased donor kidney transplants (KT). While use of higher KDPI kidneys is associated with worse outcomes, current literature still outlines its benefit in lowering overall cumulative mortality by increasing access to donor kidneys. However, investigation among recipients with multiple comorbidities is sparse.

Research Question or Hypothesis: We hypothesized the use of high versus low KDPI kidneys will confer worse clinical outcomes at the University of Illinois Hospital (UIH).

Study Design: This was a retrospective chart review.

Methods: Adult deceased donor isolated KT recipients at UIH between 9/1/2021 and 9/1/2022 were identified. The low KDPI cohort consisted of KT recipients with donor KDPI <85% compared to the high KDPI cohort with KDPI >85%. Primary outcome was kidney graft failure at one year post-KT (defined as death or definitive return to hemodialysis). Secondary outcomes included delayed graft function (DGF) [defined as need for dialysis within 7 days post-KT], length of hospital stay, acute rejection rates, and estimated glomerular filtration rates. A 2-tailed p<0.05 was deemed statistically significant.

Results: 174 KT recipients were identified with 160 subjects in the low KDPI cohort and 14 subjects in the high KDPI cohort. At one year, kidney graft failure was higher in the high KDPI cohort vs low KDPI (28.6% vs 8.8%, p=0.020). There were no differences in DGF (35.7% vs 20%, p=0.168), length of hospital stay (7.5 days vs 6 days, p=0.053), or acute rejection rates (35.7 vs 33.8 per 100 persons, p=0.882). Estimated glomerular filtration rates were lower in the high KDPI cohort at 3, 6, and 12 months post-KT.

Conclusion: These results suggest at UIH, the use of high KDPI kidneys is associated with worse outcomes in kidney graft failure and 1-year eGFR, but no difference in other transplant outcomes compared with low KDPI kidneys.

Presenting Author

Carrie Yu PharmD
University at Buffalo School of Pharmacy and Pharmaceutical Sciences

Authors

Maya Campara PharmD, BCTXP, FCCP, FAST
Kristin Heagler PharmD
University of Illinois Hospital

Dana Pierce PharmD, BCTXP
University of Illinois at Chicago, College of Pharmacy