Original Research
Monday, October 14, 2024
01:00 PM–02:30 PM
Abstract
Introduction: Limited data exists comparing the efficacy of liraglutide and semaglutide in managing weight loss.
Research Question or Hypothesis: Which drug is more effective in managing weight loss?
Study Design: A retrospective observational cohort study.
Methods: This study was conducted at a quaternary care hospital from June 2018 to July 2022, including adults who received either liraglutide or semaglutide. The primary outcome was weight loss, while secondary outcomes included effects on HbA1C and lipid profile.
Results: A total of 366 patients were analyzed: 122 received liraglutide and 244 received semaglutide. The mean age was 51.00±11.55 years in the liraglutide group and 51.16±12.35 years in the semaglutide group (p=0.521). The baseline mean weight was 94.7±19.5 kg in the liraglutide group and 94.6±19.9 kg in the semaglutide group (p=0.989). After a median follow-up of 10 (6-17) months for the liraglutide group and 7.5 (6-11) months for the semaglutide group (p<0.001), the resultant weights were 90.8±19.6 kg for the liraglutide group and 91.1±19.8 kg for the semaglutide group (p<0.001) when comparing each group to its baseline separately. When comparing the weight loss achieved in each group, liraglutide achieved a median weight loss of -4 (-7-0) kg versus -3 (-6-0) kg for semaglutide (p=0.867). The reduction in HbA1C with liraglutide was significantly less than with semaglutide: -0.2 (-0.5-0.3) versus -0.5 (-1.1-0.1) (p=0.003). Both drugs significantly lowered LDL and triglycerides. Multivariate linear regression analysis confirmed no significant difference between the drugs [B -0.577, 95% CI -1.87 to 0.7; P=0.38], while baseline weight, diabetes, and SGLT2I were significant factors affecting weight.
Conclusion: Both liraglutide and semaglutide were effective in reducing weight, with no significant difference between the two drugs. Further large-scale prospective studies are necessary to confirm these findings
Presenting Author
Wasim Elnekidy PharmD, BCPS, BCACPCleveland Clinic Abu Dhabi
Authors
Emna Abidi PhD
Cleveland Clinic Abu Dhabi
Layth Al Sayegh PharmD
Cleveland Clinic Abu Dhabi
Raya Al-Zayadeen PharmD
Cleveland Clinic Abu Dhabi
Ruba Dajani PharmD
Cleveland Clinic Abu Dhabi
Samer El-Kaissi MD
Cleveland Clinic Abu Dhabi
Haneen Hasan BSc Pharm
Cleveland Clinic Abu Dhabi
Safa Hegazin MD
Cleveland Clinic Abu Dhabi
Jihad Mallat MD
Cleveland Clinic Abu Dhabi