Scientific Poster Session II - Late Breaking Original Research

Late Breaking Original Research
  Sunday, October 13, 2024
  12:45 PM–02:15 PM

Abstract

Introduction: Identification and intervention of drug-related problems (DRPs) is a cornerstone for pharmaceutical care. An effective classification system of DRPs enables to identify the origin of DRPs and improve performance management of pharmacists. However, a standardized DRPs classification system tailored to the Chinese healthcare environment has not been established.

Research Question or Hypothesis: To establish and validate Pharmacist Intervention Evaluation (PIE) System, which is a modified Pharmaceutical Care Network Europe (PCNE) DRPs classification system, and further compared the efficacy, acceptability, and feasibility with PCNE system in tertiary hospitals in China.

Study Design: Prospective, multi-center, observational study design.

Methods: PIE system, consisting of 6 primary and 27 secondary categories, was constructed and validated through expert consensus and multi-center prospective studies. A total of 529 DRP reports were identified, intervened, and recorded by clinical pharmacists according to PCNE and PIE systems, respectively. The classification efficacy, acceptability, and feasibility of the two systems were compared. Multivariate regression analysis was employed to identify factors associated with classification efficacy of PIE system.

Results: PIE system achieved a significant higher classification efficacy than PCNE system (90.54% vs. 73.72%, p<0.05). Better acceptability and feasibility were also exhibited in PIE system compared with PCNE system (4.2±0.83 vs. 3.7±1.07, p=0.113). Multivariate regression analyses identified drug prescribing (OR=8.768, p=0.000) and dispensing process (OR=8.178, p=0.000) as two vital factors associated with DRPs classification in PIE system.

Conclusion: PIE system, a modified DRPs classification system that fitted Chinese healthcare settings was established and validated. PIE system demonstrated higher classification efficacy, acceptability, and feasibility than PCNE system in Chinese tertiary hospitals. Drug prescribing and dispensing process are the factors that dominated the classification efficacy in PIE system.

Presenting Author

Yanxiao Xiang Ph.D
Qilu Hospital of Shandong University

Authors

Jinyu Cui MD
Qilu Hospital of Shandong University

Xiaoyi Guo MD
Qilu Hospital of Shandong University

Chunlei Li Ph.D
Qilu Hospital of Shandong University

Anchang Liu Ph.D
Qilu Hospital of Shandong University