Scientific Poster Session III - Residents and Fellows Research-in-Progress

Residents and Fellows Research in Progress
  Monday, October 14, 2024
  01:00 PM–02:30 PM

Abstract

Introduction: Using direct oral anticoagulants (DOACs) during acute kidney injury (AKI) creates safety concerns. Previous studies show both increased and decreased risk of bleeding, and are limited by small sample sizes, use of non-standardized anti-Xa monitoring, and mostly evaluated apixaban. This study investigates the safety of DOACs in the context of AKI, with a focus on the rate of bleeding events.

Research Question or Hypothesis: Does using DOACs in patients with AKI lead to increased bleeding events?

Study Design: This is a multi-center, retrospective cohort study designed to assess the safety of DOACs in hospitalized patients with AKI.

Methods: Adult patients hospitalized from October 1st, 2022 to September 1st, 2023, who received a DOAC for at least 48 hours or those who had a DOAC on their home medication list were included. Patients admitted to the intensive care unit, who received dialysis, were missing a baseline serum creatinine, or were pregnant during the study period were excluded. Outcomes for patients who received a DOAC and had AKI (defined by ICD-10 code) are compared to patients who received a DOAC and did not have AKI. Major bleeding identified by ICD-10 codes is the primary endpoint. Secondary endpoints include hospital length of stay, hospital mortality, fatal bleeding, quantity of packed red blood cells received, 7-day and 30-day all-cause readmissions, and total decrease in amount (g/dL) of hemoglobin from baseline. Outcomes will be compared using a Chi-square or Fischer’s exact test with alpha set at 0.05. In addition to descriptive statistics, T-tests or Wilcoxon rank tests will be employed for continuous variables.

Results: Data collection is currently in progress.

Conclusion: To be determined based on the results of the final analysis.

Presenting Author

Kyle Furlow PharmD, MHIIM, BCPS
Emory University Hospital

Authors

Marion Javellana PharmD
Mercer University College of Pharmacy

Hannah Leschorn PharmD, BCPS
Emory University Hospital Midtown

Taylor Merritt PharmD
Emory University Hospital

Nicole Metzger PharmD, BCPS
Emory University Hospital

Carrie Tilton PharmD, BCPS
Emory University Hospital

Amanda Van Prooyen PharmD, BCPS
Emory University Hospital Midtown