Scientific Poster Session IV - Students Research-in-Progress

Abstract

Research Question or Hypothesis: What are the current management practices for VFS among non-critically ill, hospitalized pediatric patients at a children’s hospital within a large academic medical center?

Study Design: This was a single-center, retrospective review.

Methods: This study examined pediatric patients (=18 years) who received =1 dose of IV vancomycin and experienced VFS during hospital admission between January 1, 2017, and December 31, 2023. Patients were excluded if admitted to the ICU during VFS management or if the history of reaction was reported by outside hospitals (OSH) or families. The primary endpoint is management strategy, including prolonged infusion time, antihistamine administration, or switching to an alternative antibiotic. Additional data collected include vancomycin dose and concentration, and concomitant use of other histaminergic agents.

Results: Among 322 patients screened, 190 patients met the inclusion criteria for analysis. Included patients were 46% female, 60% white, 12% Black, 1% Asian, 0.5% American Indian/Alaska Native, 25% other race, 24% Hispanic and 75% non-Hispanic. Descriptive statistics were utilized to evaluate management strategies. Exclusion reasons included history of reaction reported by OSH or family (n=33), reaction occurred in PICU (n=12), unclear date/time of reaction (n=11), antimicrobial coverage discontinued before management could be assessed (n=12), deleted or erroneous reported allergy (n=3), or non-VFS reaction to vancomycin (n=2).

Conclusion: This novel study characterizes the initial management of VFS in hospitalized pediatric patients. The results will inform internal guidelines and standardize management practices at this institution.

Presenting Author

Authors