The Great Vasoplegia Debate: Red, Blue, or Renin?

Wednesday, September 16, 2025 | 12:00–1:00 PM CDT | Virtual

Contact Hours: 1.0
Target Audience: Pharmacists, pharmacy residents, pharmacy fellows, student pharmacists
UAN: 0217-0000-25-191-H01-P 
Activity Type: Knowledge

Description:

Vasoplegia remains one of the most challenging forms of shock to manage in the critically ill, particularly when conventional vasopressors fail to restore vascular tone. As emerging therapies gain traction, clinicians are faced with the question: which agent is best when the pressure is on? This 60-minute, debate-style continuing education session will feature three critical care pharmacists each championing a different pharmacologic strategy for vasoplegia: angiotensin II, methylene blue, and hydroxocobalamin. Through a series of rapid-fire arguments, rebuttals, and interactive polling questions, participants will explore the pharmacology, clinical evidence, and practical considerations for each agent. The session will be divided into three focused segments, each highlighting a specific agent’s mechanism of action, supporting data, and role in therapy. Real-world clinical scenarios will serve as the backdrop for discussion, allowing attendees to critically evaluate the strengths and limitations of each approach. Audience polling will be used throughout to engage participants and gauge shifts in opinion as the debate unfolds. Whether you're team Blue, Red, or Renin, this session will challenge your assumptions and sharpen your decision-making in the management of refractory vasoplegia.​

Learning Objectives:

1. Describe the clinical trial evidence for angiotensin-II in the treatment of catecholamine-resistant vasoplegia.
2. Explain the pharmacologic rationale of methylene blue in the management of vasoplegic shock.
3. Identify the proposed mechanisms, clinical scenarios, and limitations of hydroxocobalamin use in vasoplegia, including its role as an alternative when other therapies are contraindicated.

Speakers:

Andy Jatis, Pharm.D., BCPS, BCCCP
Clinical Pharmacist CT Surg ICU
Northwestern Memorial Hospital
Chicago, Illinois

Ashley Taylor, Pharm.D., BCCCP
CVT Surg Clinical Pharmacist
Wellstart MCG Health
Augusta, Georgia

Pamela Simone, Pharm.D., BCCP, AACC
Clinical Pharmacist Specialist, CTICU
UChicago Medicine
Chicago, Illinois

Technical Requirements

This webinar will be conducted on Zoom. View Zoom System Requirements.

Commercial Support

The American College of Clinical Pharmacy does not solicit or accept external commercial/financial support for its continuing pharmacy education activities. No commercial/financial support has been solicited or accepted for this activity.

Continuing Pharmacy Education Credit

The American College of Clinical Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

To obtain your CPE credit after the event, please visit www.accp.com, sign in, and complete the attestation statement related to this activity. You must claim your CPE by November 15, 2025. Statements of credit will be available via CPE Monitor within 2–3 business days of claiming credit. ACCP cannot issue CPE credit to any participant who does not have a date of birth and NABP e-Profile ID number on file with ACCP. Credit will not be awarded after November 15, 2025.