Too Much, Too Little, or Just Right? Beta-Lactam TDM in the ICU

Thursday, August 6, 2026 | 2:00–3:00 PM CDT | Virtual

Contact Hours: 1.0
Target Audience: Pharmacists
UAN: 0217-0000-26-182-L01-P
Activity Type: Knowledge

Description:

Beta-lactam antibiotics remain cornerstone therapies for the management of severe infections in critically ill patients; however, standard dosing approaches frequently fail to achieve optimal pharmacokinetic and pharmacodynamic (PK/PD) targets in this population. Physiologic derangements associated with critical illness, including altered volume of distribution, dynamic renal function, hypoalbuminemia, and the use of extracorporeal support, can result in highly variable beta-lactam exposure, increasing the risk of both treatment failure and toxicity. Therapeutic drug monitoring (TDM) has emerged as a potential strategy to individualize beta-lactam dosing, yet questions remain regarding its clinical evidence, optimal application, and feasibility in routine practice. This 60-minute collaborative educational session between the Critical Care and Infectious Diseases PRNs will explore the evolving role of beta-lactam TDM in critically ill patient populations.

Learning Objectives:

1. Describe how physiologic changes associated with critical illness affect the pharmacokinetics and
   pharmacodynamics of beta-lactam antibiotics.
2. Summarize the current evidence evaluating beta-lactam therapeutic drug monitoring in critically ill patients,
   including reported efficacy and safety outcomes.
3. Discuss key implementation and practical considerations for beta-lactam therapeutic drug monitoring.
4. Explain key principles and considerations used to inform beta-lactam dosing and monitoring strategies in
   critically ill patient populations.

Speakers:

Erin Frazee Barreto, Pharm.D., PhD, BCCP, FCCM, FASN
Critical Care Clinical Pharmacist and Assistant Professor
Mayo Clinic
Rochester, MN

Barbara A. Santevecchi, Pharm.D., BCIDP
Infectious Diseases Clinical Pharmacy Specialist and Assistant Professor
University of Florida Health Shands Hospital
Gainesville, FL

Technical Requirements

This webinar will be conducted on Zoom. View Zoom System Requirements.

Commercial Support

The American College of Clinical Pharmacy does not solicit or accept external commercial/financial support for its continuing pharmacy education activities. No commercial/financial support has been solicited or accepted for this activity.

Continuing Pharmacy Education Credit

The American College of Clinical Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

To obtain your CPE credit after the event, please visit www.accp.com, sign in, and complete the attestation statement related to this activity. You must claim your CPE by October 5, 2026. Statements of credit will be available via CPE Monitor within 2–3 business days of claiming credit. ACCP cannot issue CPE credit to any participant who does not have a date of birth and NABP e-Profile ID number on file with ACCP. Credit will not be awarded after October 5, 2026.