Chapter: Multimodal Analgosedation in the Critically Ill

1. Justify the use of analgosedation in critically ill patients.
2. Evaluate the risks and benefits of using volatile anesthetics and ketamine for managing sedation in the ICU.
3. Evaluate the risks and benefits of using dexmedetomidine and lidocaine for managing pain in the ICU.
4. Evaluate evidence involving the use of alternative dosage forms and routes for non-opioid analgesics for analgosedation and identify when they should be used.
5. Design an appropriate analgosedation regimen in the intensive care unit taking patientspecific factors into consideration. 

Chapter: Opioid Use Disorder in the Critically Ill

1. Distinguish terminology and definitions used for the management of patients with opioid use disorder (OUD).
2. Assess patients for potential initiation of medications for opioid use disorder (MOUD).
3. Evaluate patients for continuation of MOUD in the critical care setting.
4. Design an opioid-based analgesic regimen for patients with OUD on MOUD with acute pain in critical care units.
5. Evaluate adjunctive analgesic options for critically ill patients with OUD on MOUD in the ED and critical care unit experiencing pain. 

Chapter: Perioperative Pain Management, Enhanced Recovery, and Medication Safety

1. Assess key areas of pharmacotherapeutic intervention by clinical pharmacy services in the perioperative area.
2. Evaluate and optimize evidence-based perioperative analgesia for patients undergoing surgical intervention.
3. Devise a treatment strategy for a patient with suspected local anesthetic toxicity.
4. Apply enhanced recovery concepts to surgical patients requiring ICU-level care.
5. Justify strategies to mitigate medication safety risk points in perioperative areas. 

Chapter: End-of-Life Care in the ICU

1. Design a successful transition to comfort measures in the ICU.
2. Develop pharmacologic and nonpharmacologic therapy plans for symptom management at the end-of-life.
3. Give an opinion on the ethical complexities surrounding end-of-life care. 

Chapter: Toxicology Part 1: Selected Topics in Toxicology

1. Evaluate the benefits and risks of alternative dosing strategies for N-acetylcysteine in acetaminophen poisoning.
2. Design a multimodal treatment regimen for a patient with massive acetaminophen overdose.
3. Distinguish between mild/moderate and severe poisonings with bupropion and venlafaxine.
4. Develop a comprehensive treatment plan for patients with potentially fatal antidepressant overdoses.
5. Assess available evidence for alternative therapies for refractory β-blocker and calcium channel-blocker toxicity.
6. Evaluate the major differences between Fab and F(ab′)2 antivenoms in the treatment of North American pit viper envenomation. 

Chapter: Toxicology Part 2: Emerging Drugs of Abuse and Off-Label Medication Use

1. Evaluate patients for signs of toxicity from emerging drugs of abuse.
2. Develop a treatment plan for the patient presenting with toxicities from an emerging drug of abuse.
3. Distinguish possible exposures and toxicities in patients using prescription and nonprescription substances off-label for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection/coronavirus disease 2019 (COVID-19) prevention or treatment.
4. Design a treatment strategy for toxicities associated with off-label use of medications associated with SARS-CoV-2 infection/COVID-19. 

Interactive Case: Opioid Therapy Across the Critical Care Continuum

1. Evaluate the appropriateness of opioid therapy according to pharmacodynamics, pharmacokinetic profile, and product formulation.
2. Develop an optimal initial opioid regimen for patients upon ICU admission on the basis of clinically relevant patient characteristics.
3. Develop an appropriate strategy using enteral opioid therapy to transition from intravenous opioid therapy.
4. Assess a patient’s risk of chronic intensive care–related pain and ICU-acquired opioid dependence.
5. Assess an opioid tapering and monitoring plan for a patient transitioning out of the critical care unit or after hospital discharge. 

Interactive Case: Pain Management Services and Practice Models

1. Evaluate the impact of a pain management, palliative care (PC), addiction medicine, or opioid stewardship (OS) intervention on relevant outcomes.
2. Classify common roles and expectations of pharmacists specializing in pain, PC, addiction medicine, or OS.
3. Develop goals and metrics for pain, PC, addiction medicine, and OS outcomes.
4. Justify collaboration between critical care pharmacists and pain/palliative/addiction medicine pharmacy specialists to improve processes related to direct patient care. 

Interactive Case: Newer Research Study Designs and Analyses

1. Classify noninferiority trials, pragmatic trials, adaptive study trials, and cluster randomized clinical trials.
2. Evaluate a noninferiority trial’s study design and develop a personal strategy for interpreting its results.
3. Delineate the role and place in the clinical study design of pragmatic trials, and develop a personal strategy for interpreting the results of a pragmatic study.
4. Distinguish the different types of adaptations used in an adaptive study, and develop a personal strategy for interpreting the results of a trial with an adaptive study design.
5. Assess the risk-benefit of using a cluster randomized clinical trial design.