1. Apply knowledge of the definition, epidemiology, morbidity, and mortality of atrial fibrillation (AF) in patients with critical illness.

2. Distinguish the mechanism and pathophysiology of AF in patients with critical illness and how it differs from the presentation seen in the community, including the different adverse clinical effects of AF in patients with critical illness.

3. Develop treatment for patients with AF in different clinical scenarios, as well as in special populations with respect to the hemodynamic adverse effects of AF.

4. Design prevention of thromboembolic events caused by AF in patients with critical illness, including the management of anticoagulants in special populations and various clinical scenarios.

1. Design a treatment plan for managing acute ischemic stroke (AIS) from prevention to presentation to secondary prevention.

2. Distinguish the potential therapeutic differences between alteplase and tenecteplase for the treatment of AIS.

3. Evaluate the pharmacotherapy needs of common neuroendovascular procedures.

4. Analyze available evidence for the use of intra-arterial vasodilators for the treatment of cerebral vasospasm.

5. Develop a treatment plan for special populations requiring neuroendovascular intervention.

1. Evaluate emerging diagnostic strategies and biomarkers for acute respiratory distress syndrome (ARDS).

2. Distinguish the impact of ventilator and oxygen-support strategies in improving outcomes in patients with ARDS.

3. Assess the role of nonpharmacologic interventions in the management of ARDS.

4. Critically analyze the latest evidence-based guidelines and advances in the pharmacologic management of ARDS.

1. Apply knowledge of epidemiology, clinical significance, and guideline updates of pain, agitation, and delirium and their implications for long-term ICU outcomes.

2. Design an evidence-based multimodal pain management regimen tailored to the needs of critically ill patients in the ICU.

3. Design indication-based sedation strategies for critically ill patients by incorporating clinical context, patient comorbidities, and risk of adverse effects.

4. Evaluate the place in therapy for emerging therapies for deep sedation in special ICU populations.

5. Evaluate the evidence for established and novel pharmacotherapy agents in the prevention and treatment of ICU delirium.

1. Distinguish the physiologic changes related to pregnancy and the associated pharmacokinetic alterations of medications.

2. Identify how pregnancy affects the diagnosis of common conditions in critically ill patients and their related pharmacotherapy.

3. Demonstrate an understanding of obstetric emergencies and the clinical manifestations of each.

4. Design a pharmacotherapy treatment plan for the critically ill patient with an obstetric emergency.

1. Evaluate the primary literature and guideline recommendations for the management of heparin-induced thrombocytopenia.

2. Recommend evidence-based pharmacotherapy for the management of thrombotic microangiopathies.

3. Assess contemporary evidence for the management of primary immune thrombocytopenia.

4. Design a treatment plan for the management of thrombocytopenia in a critically ill patient.

5. Distinguish between potential causes of thrombocytopenia in a critically ill patient.

1. Distinguish the characteristics of necrotizing infections by outlining the presentation and associated outcomes.

2. Analyze the classification, diagnosis, and pathogens associated with necrotizing infections in critically ill patients.

3. Evaluate the antimicrobial management strategies for necrotizing infections incorporating recent literature and controversies.

4. Design an antimicrobial regimen that incorporates transitions of care principles.

5. Assess the role of critical care pharmacists in optimizing treatment of the disease state.

1. Design an initial management strategy for the burned multisystem trauma patient according to injury severity.

2. Design a plan for fluid resuscitation after significant burn injury and multisystem trauma.

3. Assess signs of coagulopathy after acute burn and traumatic injuries.

4. Evaluate risk-benefit of surgical intervention in the acutely burned multisystem trauma patient.

5. Formulate a patient-centered nutrition plan after significant burn and traumatic injuries.

6. Develop a supportive care regimen for patients with acute burn and traumatic injuries.

1. Design and implement an impulse control medication regimen for the management of patients with acute aortic syndrome.

2. Justify anticoagulant and antiplatelet therapy in the management of mesenteric ischemia and extracranial cervical artery dissection.

3. Evaluate the role of localized thrombolytic and vasodilator therapy in patients with acute limb ischemic injuries.

4. Develop a course of treatment for acute pulmonary embolism, taking into consideration risk stratification and response to therapy.

1. Assess the potential roles for artificial intelligence (AI) applications in the realm of critical care medicine.

2. Judge the potential utility of a model based on design and performance characteristics.

3. Apply AI principles to relevant domains in critical care medicine.

4. Detect potential concerns with the design or performance of reported model based on information provided.

5. Evaluate AI tools based on reported qualities and metrics.

6. Analyze the future landscape of AI applications in critical care to determine potential impacts on pharmacy practice, as well as potential roles for pharmacists in the design, assessment, implementation, and monitoring of AI tools.