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PSAP 2025 Book 1 (Cardiology)


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The latest release in ACCP’s popular Pharmacotherapy Self-Assessment Program (PSAP) provides timely and comprehensive updates on selected topics in cardiovascular care.  The target audience for PSAP 2025 Book 1 (Cardiology) is pharmacotherapy specialists and advanced-level clinical pharmacists whose practice involves treating patients with cardiovascular conditions commonly seen in outpatient and inpatient settings as well a preventive health and patient monitoring.

Nicholas W. Carris, Pharm.D., FCCP, BCPS
Nicholas W. Carris, Pharm.D., FCCP, BCPS

Cardiology contains nine learning elements offering a total of 18.5 available continuing pharmacy education (CPE) and/or BCPS recertification credits. Each learning activity may be taken individually for CPE credit. The book content was developed under the leadership of Nicholas W. Carris, Pharm.D., FCCP, BCPS, Associate Professor, Department of Pharmacotherapeutics and Clinical Research, Taneja College of Pharmacy, University of South Florida, Tampa, Florida.

Continuing education activities in PSAP cover the most recent published data (past 3–5 years) on a specific therapeutic area or patient-care problem. Learning content is provided as an electronic book (interactive PDF) with high-level updates in up to three formats, as appropriate to the topic:

  • Traditional chapters reviewing the latest published evidence on a therapeutic or practice-related topic
  • Case series (each section of learning content is bookended by a sample case and its explained answer)
  • Recorded webcast (a PowerPoint presentation provided as an MP4 file as well as a PDF of slides and transcribed narrative)

Every PSAP release comes in two full-color online formats: (1) interactive PDFs you can save to your desktop or print; and (2) an e-media version you can view on an e-reader, tablet, iOS or Android smart phone. Learning elements are also provided in audio form (MP3 files) as the popular PSAP Audio Companion. For an additional fee, a one-color softbound print book can be added to these formats and shipped to your address.

All PSAP chapters are fully referenced, with clickable hyperlinks to literature compilers such as PubMed. Other links provide ready access to clinical practice guidelines, official recommendations, and patient assessment tools. Graphic features focus on pivotal studies, patient care scenarios, and take-home points that can be readily integrated into clinical practice.

Release Date: January 15, 2025
BCPS Deadline: July 15, 2025
ACPE Deadline: January 15, 2028

Contents

PSAP 2025 Book 1, Chapter: Hypertension

Appropriate hypertension treatment is crucial, with one study showing mortality risk from stroke, heart, or vascular disease doubling with increases in SBP of 20 mm Hg and DBP of 10 mm Hg from a baseline of 115/75 mm Hg (Lewington 2002), and another study showing a 53% increase in atherosclerotic cardiovascular disease (ASCVD) for every 10-mm Hg increase in SBP above 90 mm Hg (Whelton 2020).

PSAP 2025 Book 1, Chapter: Complex Lipid Management

Cardiovascular disease (CVD), particularly atherothrombotic diseases, remains the leading cause of death in adults in the United States (CDC 2024), and more than 10% of adults older than 21 are reported to have clinical atherosclerotic CVD (ASCVD) (Gu 2022).

PSAP 2025 Book 1, Recorded Webcast: Behavioral Approaches to Optimize Patient Engagement in a Healthy Lifestyle

Lifestyle modification plays an important role in the prevention and treatment of multiple cardiovascular-related conditions.

PSAP 2025 Book 1, Chapter: Heart Failure with Preserved Ejection Fraction

Heart failure (HF) is a clinical syndrome characterized by signs and symptoms of volume overload, dyspnea, exercise intolerance, and fatigue that result from impairments in left ventricular (LV) contraction or filling.

PSAP 2025 Book 1, Chapter: Transitions of Care After Acute Coronary Syndrome

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality globally, and in the United States. It is the leading cause of death for people of most racial and ethnic groups (Virani 2023).

PSAP 2025 Book 1, Case Series: Orthostatic Hypertension

Orthostatic hypotension (OH) is defined as a reduction of 20 mm Hg or greater in systolic blood pressure (SBP) or 10 mm Hg or greater in diastolic blood pressure (DBP) with assumption of an upright position (Shen 2017).

PSAP 2025 Book 1, Chapter: Venous Thromboembolism: Primary Prevention

Venous thromboembolism (VTE) is the third most common cause of cardiovascular mortality worldwide, exceeded only by stroke and myocardial infarction (Wendelboe 2016).

PSAP 2025 Book 1, Chapter: Antithrombotic Therapy for Valvular Heart Disease

Valvular heart disease (VHD) is a pathological process characterized by cardiac valve dysfunction and is a leading cause of cardiovascular morbidity and mortality.

PSAP 2025 Book 1, Chapter: ECG Interpretation and Management of QT Prolongation

The electrocardiogram (ECG) is a quick, non-invasive diagnostic study that provides a wealth of information about cardiac electrophysiology, myocardial structure, and function.

PSAP 2025 Book 1, Chapter: Hypertension

Faculty

Andrew Hwang, Pharm.D., BCPS

Associate Professor, MCPHS University School of Pharmacy, Boston, Massachusetts

Christina H. Sherrill, Pharm.D., BCACP, BC-ADM

Associate Professor, UNC Eshelman School of Pharmacy

Reviewers

Rachel Khan, Pharm.D., BCPS

Associate Professor
VCU School of Pharmacy
Glen Allen, VA

Samira Zantout, Pharm.D., BCIDP, BCPS

Clinical Pharmacist
Avera McKennan
Sioux Falls, SD

Jessica Reno, Pharm.D., BCPS, BSN, RN, MEDSURG-BC

Cardiology Clinical Pharmacy Specialist
Cleveland Clinic
Ravenna, OH

PSAP 2025 Book 1, Chapter: Complex Lipid Management

Faculty

Maria C. (Pruchnicki) Coyle, Pharm.D., B.S.Pharm, FCCP, BCACP, BCPS, CLS
Associate Professor – Clinical, The Ohio State University College of Pharmacy, and Specialty Pharmacist - Ambulatory, The Ohio State University Wexner Medical Center, Columbus, Ohio
Erica Davidson, Pharm.D., BCACP, CLS, ACE

Reviewers

Michael S. Kelly, Pharm.D., BCACP, CDCES, CLS
Assistant Professor – Department of Pharmacy Practice
Chapman University School of Pharmacy
Irvine, California
Rebecca Y. Cheung, Pharm.D., BCPS

Research Pharmacist
Dana-Farber Cancer Institute
Boston, MA

Kellie J. Goodlet, Pharm.D., BCIDP, BCPS, BCTXP

Associate Professor
Department of Pharmacy Practice, Midwestern University
Glendale, AZ

PSAP 2025 Book 1, Recorded Webcast: Behavioral Approaches to Optimize Patient Engagement in a Healthy Lifestyle

Faculty

Lauren M. Hynicka, Pharm.D., BCPS, RYT-200

Associate Professor of Pharmacotherapy, University of Maryland School of Pharmacy, Baltimore, Maryland

Richard J. Rovelli, Pharm.D., BCCP

Clinical Pharmacy Specialist - Cardiology University of Maryland Medical Center

Reviewers

Jason Isch, Pharm.D., BCACP

Assistant Professor of Pharmacy Practice, Manchester University
Ambulatory Care Clinical Pharmacist, Saint Joseph Health System
South Bend, Indiana

Janet M. Bramell, Pharm.D., BCOP, BCPS

Clinical Pharmacy Practitioner, Oncology VA Tennessee Valley Healthcare System

Richard Chan, Pharm.D., BCPS

Internal Medicine Clinical Pharmacy Specialist

PSAP 2025 Book 1, Chapter: Heart Failure with Preserved Ejection Fraction

Faculty

Aimon C. Miranda, Pharm.D., BCPS
Cyrille Cornelio, Pharm.D., BCCP

Reviewers

Sandeep Devabhakthuni, BCCP, BCPS

University of Maryland School of Pharmacy

Patrick D. Roland, Pharm.D., BCPS

Pharmacist Baptist Health Hardin

Jennifer L. Polyniak, Pharm.D., BCCCP, BCPS

PSAP 2025 Book 1, Chapter: Transitions of Care After Acute Coronary Syndrome

Faculty

Joel C. Marrs, Pharm.D., MPH, FCCP, FAHA, FASHP, FNLA, BCACP, BCCP, BCPS, CLS

Professor and Coordinator of Clinical Outreach University of Tennessee Health Science Center College of Pharmacy

Reviewers

Eric A. Dietrich, Pharm.D., BCACP

Postdoctoral Fellow University of Florida

Paul M. Boylan, Pharm.D., BCPS

Associate Professor The University of Oklahoma College of Pharmacy

Shereen Ahmad Dasuqi, BCCCP, BCPS

Clinical Pharmacist KSUMC

PSAP 2025 Book 1, Case Series: Orthostatic Hypertension

Faculty

Elizabeth Pogge, Pharm.D., MPH, BCGP, BCPS

Reviewers

Anthony Ishak, Pharm.D., BCPS

Ambulatory Care Clinical Pharmacist, Beth Israel Deaconess Medical Center

Arlene A. Thomas, Pharm.D., BCPS
Olga Hilas, Pharm.D., BCGP, BCPS

Associate Clinical Professor, Clinical Pharmacy Practice, St. John’s University, Queens, New York

PSAP 2025 Book 1, Chapter: Venous Thromboembolism: Primary Prevention

Faculty

Allison Burnett, Pharm.D.

Antithrombosis Stewardship Pharmacist, University of New Mexico Hospital;
President, Anticoagulation Forum
Albuquerque, New Mexico

Kathryn Dane, Pharm.D., BCPS

Clinical Pharmacy Specialist – Benign Hematology and Cardiology,
Co-Director – Hemostatic and Antithrombotic Stewardship Program
The Johns Hopkins Hospital
Baltimore, Maryland

Reviewers

Gabriel V. Fontaine, Pharm.D., MBA, FNCS, FCCM, BCCCP, BCPS

Clinical Pharmacy Manager, Critical Care, Emergency Medicine, TeleCritical Care Intermountain Health - Intermountain Medical Center

Grace E. Barr, Pharm.D., BCPS

Assistant Professor of Pharmacy Practice Campbell University College of Pharmacy & Health Sciences

Abby L. Gallagher, Pharm.D., MHS, BCPS

Clinical Pharmacist Cleveland Clinic

PSAP 2025 Book 1, Chapter: Antithrombotic Therapy for Valvular Heart Disease

Faculty

Kelly M. Rudd, Pharm.D., FCCP, BCPS, CACP

Clinical Associate Professor of Medicine - Oklahoma State University Center for Health Sciences College of Osteopathic Medicine, Tulsa, Oklahoma

Clinical Pharmacy Specialist - Indian Health Service, Claremore, Oklahoma

Amanda Winans, Pharm.D., BCPS, CACP

Clinical Pharmacy Specialist, Bassett Medical Center, Cooperstown, New York

Reviewers

Toby C. Trujillo, Pharm.D., FCCP, FAHA, BCPS

Professor of Clinical Pharmacy
University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences
Aurora, Colorado 

Ahmed A. Shible, Pharm.D., BCCCP, BCPS

Clinical Coordinator University of North Carolina Rex Hospital

Jenna E. Januszka, Pharm.D., BCPS, AAHIVP

Clinical Pharmacist Practitioner
Duke University Hospital, Infectious Disease Clinic;
Adjunct Assistant Professor
UNC Eshelman School of Pharmacy

PSAP 2025 Book 1, Chapter: ECG Interpretation and Management of QT Prolongation

Faculty

Zachary R. Noel, Pharm.D., Ph.D., BCCP

Assistant Professor
University of Maryland School of Pharmacy
Baltimore, Maryland

Joseph S. Van Tuyl, Pharm.D., BCCP

Associate Professor St. Louis College of Pharmacy at UHSP

Reviewers

Jessica Carey

Clinical Pharmacist University of Utah Health

Cathryn McIntosh, Pharm.D., BCCP, BCPS

Clinical Pharmacist Veterans Affairs Medical Center

Emily M. Kostelic, Pharm.D., BCPS

Internal Medical Clinical Pharmacist Atrium Health Wake Forest Baptist Health

CPE Credit

The American College of Clinical Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

The American College of Clinical Pharmacy is approved by BPS as a provider for the recertification of BCPS.

BPS is an autonomous division of the American Pharmacists Association. To maintain its strict, independent standards for certification, BPS does NOT endorse or provide review information, preparatory courses, or study guides for board certification examinations. BPS, through its specialty councils, is responsible for specialty examination content, administration, scoring, and all other aspects of its certification programs. BPS is totally separate and distinct from ACCP. For information about BPS specialty recertification the BPS recertification process, go to: www.bpsweb.org/

To receive recertification credit, posttests must be submitted prior to the recertification posttest deadline (see above). Only completed tests are eligible for credit; no partial or incomplete tests will be processed. You may complete one or all available posttests for credit.

The passing point to earn recertification credit is based on an expert analysis of the assessment items in each posttest. Any posttest submitted before the recertification test deadline that meets this passing point will earn recertification credits. These credits will be assigned as of the date of test submission and reported within 48 hours to BPS. For statements of recertification credit, visit www.bpsweb.org.

In accordance with BPS guidelines concerning remediation for products launched in 2024 and after, posttests that do not reach the passing point for recertification credit will generate a second-chance test option. This test will automatically appear in the learner’s My Account page and will have assessment items presented in a different order. To qualify for recertification credit, the second-chance test must be submitted before the recertification deadline stated above.

The ACCP Recertification Dashboard is a free online tool that can track recertification credits as they are earned through ACCP and schedule new opportunities for credits from upcoming ACCP professional development programs. Questions regarding the number of hours required for recertification should be directed to BPS at www.bpsweb.org.

Target Audience: The target audience is pharmacotherapy specialists and advanced-level clinical pharmacists whose practice involves treating patients with cardiovascular conditions commonly seen in outpatient and inpatient settings as well a preventive health and patient monitoring.

Contents

PSAP 2025 Book 1, Chapter: Hypertension

Activity Number: 0217-0000-25-010-H01-P
Contact Hour(s): 2.00
Activity Type: Application Based

Learning Objectives

1. Evaluate patient-specific factors related to the diagnosis of hypertension.

2. Analyze clinical practice guidelines and primary literature that affect current hypertension management strategies.

3. Develop an individualized hypertension treatment plan using a comprehensive approach.

4. Apply treatment strategies for patients with critical or difficult-to-treat hypertension.

 

PSAP 2025 Book 1, Chapter: Complex Lipid Management

Activity Number: 0217-0000-25-011-H01-P
Contact Hour(s): 2.00
Activity Type: Application Based

Learning Objectives

1. Demonstrate the relevance of lipid management in atherosclerotic cardiovascular disease (ASCVD) prevention.

2. Develop a contemporary approach to patient assessment for ASCVD risk, including the roles of risk-enhancing patient characteristics, coronary artery calcium (CAC) and updated lipoprotein targets, and social determinants of health.

3. Analyze emerging recommendations for absolute risk assessment of ASCVD on the basis of cardiovascular-kidney-metabolic syndromes, including the sex-specific, race-free AHA Predicting Risk of CVD Events (PREVENT) model.

4. Develop a pharmacologic treatment plan for dyslipidemia emphasizing a variety of patient subsets and situations requiring statin and non-statin therapies for low-density lipoprotein cholesterol (LDL-C) lowering.

5. Evaluate the pharmacist’s role in complex lipid management, including evidence-based strategies for collaborative practice and deploying higher-cost medications.

PSAP 2025 Book 1, Recorded Webcast: Behavioral Approaches to Optimize Patient Engagement in a Healthy Lifestyle

Activity Number: 0217-0000-25-012-H01-P
Contact Hour(s): 1.50
Activity Type: Application Based

Learning Objectives

1. Account for the effect of lifestyle decisions on the morbidity and mortality of cardiovascular disease.

2. Identify challenges that may impede a patient’s success in lifestyle changes.

3. Distinguish characteristics of health behavior theories.

4. Apply behavioral approaches to implement lifestyle modifications to a patient case.

5. Evaluate the role of technology in providing additional support for patients making lifestyle modifications.

PSAP 2025 Book 1, Chapter: Heart Failure with Preserved Ejection Fraction

Activity Number: 0217-0000-25-013-H01-P
Contact Hour(s): 2.00
Activity Type: Application Based

Learning Objectives

1. Distinguish heart failure with preserved ejection fraction (HFpEF) from other forms of HF, including HF with reduced EF (HFrEF), HF with improved EF (HFimpEF), and HF with mildly reduced EF (HFmrEF).

2. Evaluate the roles of sodium-glucose cotransporter-2 (SGLT2) inhibitors, mineralocorticoid receptor antagonists (MRAs), and angiotensin receptor-neprilysin inhibitor (ARNI) in the management of HFpEF.

3. Develop a pharmacologic treatment plan for managing HFpEF using guideline-directed medical therapy (GDMT).

4. Design a therapeutic plan to manage the common comorbidities encountered in patients with HFpEF.

5. Evaluate patients for referral to general cardiology or an HF specialist.

PSAP 2025 Book 1, Chapter: Transitions of Care After Acute Coronary Syndrome

Activity Number: 0217-0000-25-014-H01-P
Contact Hour(s): 2.00
Activity Type: Application Based

Learning Objectives

1. Identify the optimal approach to treatment decisions as patients transition to the ambulatory care environment after an ACS event, including addressing challenges, team- based care, and social determinants of health.

2. Determine key guideline recommendations for the management of patients following an ACS event for optimization of cardiovascular risk lowering therapy in the ambulatory care environment.

3. Evaluate available literature describing current controversies in cardiovascular risk lowering therapy following an ACS event, such as duration and optimization of combination antiplatelet therapy with anticoagulation.

4. Develop a pharmacologic treatment plan for managing a patient post ACS emphasizing cardiovascular risk lowering therapy based on special patient populations and guideline directed care.

5. Evaluate the pharmacist’s role in the process of transitioning care to the ambulatory care environment following an ACS event, including evidence-based strategies for collaborative practice and deploying higher-cost medications.

PSAP 2025 Book 1, Case Series: Orthostatic Hypertension

Activity Number: 0217-0000-25-015-H01-P
Contact Hour(s): 2.00
Activity Type: Application Based

Learning Objectives

1. Distinguish the pathophysiology and classifications of orthostatic hypotension (OH).

2. Assess patients for modifiable risk factors associated with the development and precipitation of OH.

3. Develop appropriate nonpharmacologic and pharmacologic treatment plans for the management of OH.

4. Evaluate concurrent health conditions that may affect therapeutic approaches for patients with OH.

5. Design evidence-based therapy for patients with OH using recent and relevant clinical practice guidelines.

PSAP 2025 Book 1, Chapter: Venous Thromboembolism: Primary Prevention

Activity Number: 0217-0000-25-016-H01-P
Contact Hour(s): 2.50
Activity Type: Application Based

Learning Objectives

1. Compare and contrast available models used to evaluate venous thromboembolism (VTE) risk in various patient populations

2. Design appropriate thromboprophylaxis regimens for at-risk patients, including special populations

3. Assess available evidence and current guideline recommendations focused on thromboprophylaxis

4. Develop strategies to incorporate antithrombosis stewardship principles into thromboprophylaxis practices

PSAP 2025 Book 1, Chapter: Antithrombotic Therapy for Valvular Heart Disease

Activity Number: 0217-0000-25-017-H01-P
Contact Hour(s): 2.50
Activity Type: Application Based

Learning Objectives

1. Analyze the associated thrombotic risks associated with valvular heart disease (VHD) repair and replacement options.

2. Develop a pharmacologic treatment plan for a variety of patient subsets and situations after VHD correction surgery that optimizes the use of guideline-directed medical therapy.

3. Identify the pharmacist’s role in anticoagulation stewardship in patients with VHD.

PSAP 2025 Book 1, Chapter: ECG Interpretation and Management of QT Prolongation

Activity Number: 0217-0000-25-018-H01-P
Contact Hour(s): 2.00
Activity Type: Application Based

Learning Objectives

1. Justify the pharmacist’s role in interpreting ECG.  

2. Evaluate and interpret normal and abnormal waveforms and intervals on an ECG.

3. Measure and calculate the QT/QTc interval using a 12-lead ECG.

4. Given a patient case and 12-lead ECG, analyze factors that influence the accuracy and reliability of the heart rate corrected QT interval (QTc).

5. Given a patient case, analyze risk factors for QT prolongation.

6. Given a patient case, provide recommendations for the management of QT prolongation.

Disclosures


Commercial Support

The American College of Clinical Pharmacy does not solicit or accept external commercial/financial support for its continuing pharmacy education activities. No commercial/financial support has been solicited or accepted for this activity.