Part One: Endocrine Resuscitation in Septic Shock
Part Two: Alternative Therapeutics for Septic Shock

• Series Overview
• Program Content
• Faculty
• Financial Relationship Disclosures
• Target Audience and Learning Objectives
• Continuing Pharmacy Education Credit
• BCCCP Specialty Recertification Credit
• Technical Requirements
• Commercial Support
• Fees

Clinical Reasoning Series in Critical Care Pharmacy has been approved by the Board of Pharmacy Specialties (BPS) as one component of the professional development programs developed by ACCP for recertification of the Board Certified Critical Care Pharmacist (BCCCP).

This educational series explores cutting-edge, contemporary therapeutic topics, and demonstrates scientifically sound clinical reasoning and decision-making. It employs learning activities designed to advance the participants' skills and abilities to critically evaluate the scientific evidence and to effectively incorporate into daily practice significant findings that lead to effective and safe patient care.

The program will consist of several educational activities and is presented in two parts with each part containing:

• streaming audio/slide synchronized presentations
• downloadable mp3 audio files
• downloadable mp4 video files
• downloadable/printable PDFs of presentation slides
• Continuing Pharmacy Education (CPE) credit
• Recertification Credit - Available with Specialty Recertification package

Release date: November 9, 2022
BCCCP credit expiration date: November 9, 2023
ACPE credit expiration date: November 9, 2025

Board Certified Critical Care Pharmacists are at the forefront of treatment of patients with sepsis. This evolving field has seen the rise and fall of multiple therapeutic interventions. While the "cure for sepsis" has yet to be discovered- there are drug classes with both old and emerging data that may offer promising therapeutics for the treatment and mitigation of this disease.

Part One: Endocrine Resuscitation in Septic Shock

This program will explore the following topics:

• Role of the endocrine system in the pathogenesis of sepsis
• Hormone supplementation as a therapeutic intervention
• Catecholamine sparing hemodynamic management strategy

Part Two: Alternative Therapeutics for Septic Shock

This program will explore the following topics:

• Overview of the immunology of sepsis
• Therapeutics to mitigate inflammation
• Identify novel agents in the pipeline for treatment of sepsis

Both programs will focus on the application of pathophysiology and pharmacology in treatment selection, as it relates to the pros and cons of the current evidence.

Clinical Reasoning Series in Critical Care Pharmacy – Program Chair

	Melissa Lynn Thompson Bastin, Pharm.D., Ph.D., FCCM Assistant Adjunct Professor, Department of Pharmacy Practice and Science University of Kentucky HealthCare University of Kentucky College of Pharmacy Lexington, Kentucky

Clinical Reasoning Series in Critical Care Pharmacy – Part One: Endocrine Resuscitation in Septic Shock

	Mahmoud Ammar, Pharm.D., FCCM, BCPS, BCCCP Critical Care Clinical Pharmacy Specialist - Trauma-Surgical Yale New Haven Health Clinical Associate Professor University of Connecticut School of Pharmacy New Haven, Connecticut
	Brittany D. Bissell, Pharm.D., Ph.D., BCCCP Assistant Professor University of Kentucky College of Medicine Assistant Professor University of Kentucky College of Pharmacy Lexington, Kentucky

Clinical Reasoning Series in Critical Care Pharmacy – Part Two: Alternative Therapeutics for Septic Shock

	Brooke Barlow, Pharm.D. Neurocritical Care Clinical Pharmacy Specialist Memorial Hermann The Woodlands Medical Center The Woodlands, Texas
	Carolyn Magee Bell, Pharm.D., BCCCP Medical-Surgical ICU Clinical Pharmacy Specialist Medical University of South Carolina (MUSC) Charleston, South Carolina

Disclosures 

TARGET AUDIENCE
The target audience for Clinical Reasoning Series in Critical Care Pharmacy is the pharmacist practicing in a clinical setting as a Board Certified Critical Care Pharmacist (BCCCP) looking to earn rectification credit, and those clinicians seeking additional information on the topics covered.

LEARNING OBJECTIVES
At the conclusion of Part One: Endocrine Resuscitation in Septic Shock, the participant should be able to:

1. Recognize the role of the endocrine system and endocrinopathy in the pathogenesis of sepsis.
2. Appraise the evidence surrounding the impact of thyroidal hormone supplementation as a therapeutic intervention in the critically ill population.
3. Examine the role of non-catecholamine vasopressors in the pathogenesis of septic shock.
4. Formulate a septic shock treatment plan using non-catecholamine vasopressors as a therapeutic intervention.

At the conclusion of Part Two: Alternative Therapeutics for Septic Shock, the participant should be able to:

1. Describe the pathophysiology of sepsis and septic shock highlighting the role of coagulation, immune, and neurohormonal system.
2. Discuss the potential role of antithrombotics, statins, beta blockers, alpha adrenergic antagonists, and immune modulation in the management of sepsis and septic shock.
3. Analyze the current literature evaluating alternative therapies in sepsis and septic shock.
4. Given a patient case, implement alternative therapies for sepsis and septic shock into clinical practice.

The American College of Clinical Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

Clinical Reasoning Series in Critical Care Pharmacy – Part One: Endocrine Resuscitation in Septic Shock
Activity Number: 0217-0000-22-230-H01-P
Contact Hours: 3.00
Activity Type: Application-Based Activity

Clinical Reasoning Series in Critical Care Pharmacy – Part Two: Alternative Therapeutics for Septic Shock
Activity Number: 0217-0000-22-231-H01-P
Contact Hours: 3.00
Activity Type: Application-Based Activity

Methods and CE Requirements

ACPE Continuing Pharmacy Education Credit
To be eligible to earn continuing pharmacy education credit, participants must purchase the product, review all content, successfully complete, submit and pass the Web-based posttest associated with each module by November 9, 2025. Only completed assessments will be eligible for credit; no partial or incomplete assessments will be processed. You are allowed only one attempt to successfully complete this assessment.

National Association of Boards of Pharmacy - CPE Monitor Service

Provided through the collaborative efforts of the National Association of Boards of Pharmacy (NABP), the Accreditation Council for Pharmacy Education (ACPE), and ACPE-accredited providers, the CPE Monitor Service allows you to electronically keep track of continuing pharmacy education (CPE) credits from ACPE-accredited providers. ACPE-accredited providers, like ACCP, are responsible for transmitting this information to NABP to be stored in the CPE Monitor system. Statements of credit will be available at CPE Monitor, nabp.pharmacy/cpe-monitor-service/, within 2–3 business days after completion of this activity. For more information on CPE Monitor please visit nabp.pharmacy/cpe-monitor-service/.

To transfer these credits to CPE Monitor on your behalf your NABP e-Profile ID Number and date of birth must be listed on your ACCP account. To verify or update this information in your ACCP account, visit Licensure/Certification. Be sure to save your changes at the bottom of the page.

Some international pharmacists do not use the CPE Monitor service. To verify or update this information in your ACCP account, visit Licensure/Certification. Check the box “I am an international pharmacist or I am not licensed to practice in the United States, and do not have an NABP e-Profile ID.” Be sure to save your changes at the bottom of the page.

To be eligible to earn BCCCP recertification credit, participants must purchase the recertification version of this course, review all content, successfully complete, submit and pass the Web-based posttest associated with each module by November 9, 2023. Only completed assessments will be eligible for credit; no partial or incomplete assessments will be processed. You are allowed only one attempt to successfully complete this assessment.

The passing point to earn BCCCP recertification credit is based on an expert analysis of the assessment items in each posttest module. Any posttest submitted before the BCCCP posttest deadline that meets this passing point will earn BCCCP recertification credits. These credits will be assigned as of the date of test submission. For statements of recertification credit, visit www.bpsweb.org.

All participants must have a Board of Pharmacy Specialties (BPS) board certification credential number, BPS ID Number, and a BPS expiration date on file with ACCP for reporting purposes. To verify or update this information in your ACCP account, visit Licensure/Certification. Be sure to save your changes at the bottom of the page.

Questions regarding the number of hours required for BCCCP recertification should be directed to BPS at (202) 946-5026 or www.bpsweb.org. The ACCP Recertification Dashboard is a free online tool that can track recertification credits as they are earned through ACCP and schedule new opportunities for credits from upcoming ACCP professional development programs.

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The American College of Clinical Pharmacy does not solicit or accept external commercial/financial support for its continuing pharmacy education activities. No commercial/financial support has been solicited or accepted for this activity.